March 18, 2011 Leave a comment
Nature Reviews Neuroscience 8, 45-56 (January 2007) | doi:10.1038/nrn2044
Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks
Gamma frequency oscillations are thought to provide a temporal structure for information processing in the brain. They contribute to cognitive functions, such as memory formation and sensory processing, and are disturbed in some psychiatric disorders. Fast-spiking, parvalbumin-expressing, soma-inhibiting interneurons have a key role in the generation of these oscillations. Experimental analysis in the hippocampus and the neocortex reveals that synapses among these interneurons are highly specialized. Computational analysis further suggests that synaptic specialization turns interneuron networks into robust gamma frequency oscillators.